HCV is a 9.6 kb positive single-stranded RNA genome that belongs to the family Flaviviridae, genus Hepacivirus. Hepatitis C virus (HCV) infection is considered a major Public Health problem, with an estimate of 200 million people infected worldwide. HCV infection is the major cause of chronic liver disease, with severe outcomes liver including cirrhosis and hepatocellular carcinoma and is the main cause of liver transplantation.