Biomedical Mutation Analysis

Positions Amino Acids

Position Mutation Antiviral Inhibitor Main References in vitro References in vivo
16C16SGS-9132ProteaseNoYang W, 2008.
36V36A/M/L/G/I/CTelaprevir, Boceprevir, Simeprevir, Vedroprevir, Danoprevir, Paritaprevir (ABT-450), Asunaprevir, Vedroprevir, Narlaprevir, PHX1766 ProteaseYesLin C, 2004.
Sheaffer, 2004.
Sarrazin C, 2007.
Tong X, 2008.
Zhou Y, 2008.
Sarrazin C, 2007.
Tong X, 2008.
Ralston R. , 2007.
Kieffer TL, 2007.
Bartels DJ, 2008.
Bartels DJ, 2013.
Barbotte L, 2010.
Kieffer TL, 2012.
Sullivan JC, 2013.
39A39VGS-9132ProteaseNoYang W, 2008.
41Q41R/K/P/HTelaprevir, Boceprevir, Danoprevir, SCH567312 ProteaseNoSheaffer, 2004.
Tong X, 2008.
Liverton NJ, 2010.
Vermehren J, 2012.
43F43S/C/Y/V/I/LTelaprevir, Boceprevir, Danoprevir, Vedroprevir, SCH567312ProteaseNoTong X, 2008.
Liverton NJ, 2010.
Vermehren J, 2012.
Kwong AD, 2011.
54T54A/S/V/G/CTelaprevir, Boceprevir, Vedroprevir, Narlaprevir, Vedroprevir, SCH567312, PHX1766 ProteaseYesSheaffer, 2004.
Sarrazin C, 2007.
Zeuzem S, 2005.
Zeuzem S, 2005.
Tong X, 2006.
Tong X, 2006.
Sarrazin C, 2007.
Tong X, 2008.
Bartels DJ, 2013.
Kieffer TL, 2012.
Kwong AD, 2011.
Curry S, 2008.
Susser S, 2009.
Gaudieri S, 2009.
Bae A, 2010.
55V55A/F/I/K/TTelaprevir, Boceprevir, Vedroprevir, Danoprevir, Paritaprevir (ABT-450), Sovaprevir, PHX1766 ProteaseYesSusser S, 2008.
Qiu P, 2009.
Bartels DJ, 2013.
Vermehren J, 2012.
Susser S, 2009.
Paolucci S, 2012.
79D79ETelaprevir, Boceprevir ProteaseNoThibeault D, 2004.
80Q80K/R/L/N/H/GTelaprevir, Boceprevir, Simeprevir, Asunaprevir, Danoprevir, Vedroprevir, Sovaprevir ProteaseYesLenz O, 2010.
Bartels DJ, 2013.
Bae A, 2010.
Paolucci S, 2012.
McPhee F, 2012.
87A87TTelaprevir, Boceprevir ProteaseNoSusser S, 2009.
Besse B, 2012.
Susser S, 2011.
105Y105CAsunaprevir ProteaseNoMcPhee F, 2012.
109R109KTelaprevir, Boceprevir, SCH446211 ProteaseNoYi M, 2006.
Bartels DJ, 2008.
117R117HTelaprevir, Boceprevir ProteaseNoSusser S, 2009.
Besse B, 2012.
Susser S, 2011.
122S122G/A/R/N/TSimeprevir ProteaseNoTong X, 2006.
McPhee F, 2012.
McPhee F, 2012.
Tong X, 2014.
123R123TTelaprevir, CiluprevirProteaseNoLin C, 2004.
Tong X, 2006.
138S138T/D/PTelaprevir, Boceprevir, DanoprevirProteaseNoSeiwert S. , 2006.
Seiwert SD, 2007.
Imhof I, 2011.
Besse B, 2012.
155R155G/K/T/M/I/L/S/Q/P/N/WTelaprevir, Boceprevir, Simeprevir, Vedroprevir, Faldaprevir, Danoprevir, Paritaprevir (ABT-450), Asunaprevir, Narlaprevir, GS9256, Grazoprevir (MK5172), BMS-791325, PHX1766 ProteaseYesLin C, 2004.
Sarrazin C, 2007.
Lu L, 2004.
Zhou Y, 2007.
Lagacé Lisette, 2012.
Sarrazin C, 2007.
Kieffer TL, 2007.
Bartels DJ, 2008.
Bartels DJ, 2013.
Susser S, 2009.
Sarrazin C, 2010.
Colson P, 2008.
156A156F/N/S/T/V/I/G/DTelaprevir, Boceprevir, Simeprevir, Vedroprevir, Faldaprevir, Danoprevir, Paritaprevir (ABT-450), Asunaprevir, Narlaprevir, GS9256, Grazoprevir (MK5172), BMS-791325, SCH567312, PHX1766 ProteaseYesLin C, 2004.
Sheaffer, 2004.
Sarrazin C, 2007.
Tong X, 2006.
Lu L, 2004.
Lin C, 2005.
He Y, 2008.
Sarrazin C, 2007.
Kieffer TL, 2007.
Hiraga N, 2011.
158V158I/MBoceprevir ProteaseYesKieffer TL, 2007.
Qiu P, 2009.
Flint M, 2009.
Bartels DJ, 2013.
Kwo PY, 2010.
163V163LBoceprevir ProteaseNoQiu P, 2009.
Taremi SS, 1998.
168D168Q/A/Y/V/E/T/N/P/I/H/G/F/S/KTelaprevir, Boceprevir, Simeprevir, Vedroprevir, Faldaprevir, Danoprevir, Paritaprevir (ABT-450), Asunaprevir, Narlaprevir, GS9256, Grazoprevir (MK5172), BMS-791325, Sovaprevir, IDX-320 ProteaseYesLin C, 2004.
Sheaffer, 2004.
Seiwert SD, 2007.
Lu L, 2004.
Lagacé Lisette, 2012.
He Y, 2008.
Koev G, 2007.
Bartels DJ, 2013.
Vermehren J, 2012.
Bae A, 2010.
Zeuzem S, 2011.
170V170A/T/G/L/MTelaprevir, Boceprevir, Simeprevir, Faldaprevir, Danoprevir, Asunaprevir, Narlaprevir, SCH567312, PHX1766 ProteaseYesZeuzem S, 2005.
Zeuzem S, 2005.
Tong X, 2006.
Bartels DJ, 2008.
Bartels DJ, 2013.
Curry S, 2008.
Susser S, 2009.
Besse B, 2012.
173E173GAsunaprevirProteaseNoMcPhee F, 2012.
174S174F/PTelaprevir, Boceprevir, Danoprevir ProteaseNoImhof I, 2011.
Besse B, 2012.
Susser S, 2011.
175M175LTelaprevir, Boceprevir ProteaseNoRomano KP, 2010.
Bartels DJ, 2013.
Paolucci S, 2012.
Barnard RJ, 2013.
176E176GTelaprevir, Boceprevir ProteaseNoFlint M, 2009.
Krieger N, 2001.
Abe K, 2007.
26 registries
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