|
|
Position |
Mutation |
Antiviral |
Inhibitor |
Main |
References in vitro |
References in vivo |
|
| 16 | C16S | GS-9132 | Protease | No | Yang W, 2008.
| |
|
| 36 | V36A/M/L/G/I/C | Telaprevir, Boceprevir, Simeprevir, Vedroprevir, Danoprevir, Paritaprevir (ABT-450), Asunaprevir, Vedroprevir, Narlaprevir, PHX1766 | Protease | Yes | Lin C, 2004.
Sheaffer, 2004.
Sarrazin C, 2007.
Tong X, 2008.
Zhou Y, 2008.
| Sarrazin C, 2007.
Tong X, 2008.
Ralston R. , 2007.
Kieffer TL, 2007.
Bartels DJ, 2008.
Bartels DJ, 2013.
Barbotte L, 2010.
Kieffer TL, 2012.
Sullivan JC, 2013.
|
|
| 39 | A39V | GS-9132 | Protease | No | Yang W, 2008.
| |
|
| 41 | Q41R/K/P/H | Telaprevir, Boceprevir, Danoprevir, SCH567312 | Protease | No | Sheaffer, 2004.
Tong X, 2008.
Liverton NJ, 2010.
| Vermehren J, 2012.
|
|
| 43 | F43S/C/Y/V/I/L | Telaprevir, Boceprevir, Danoprevir, Vedroprevir, SCH567312 | Protease | No | Tong X, 2008.
Liverton NJ, 2010.
| Vermehren J, 2012.
Kwong AD, 2011.
|
|
| 54 | T54A/S/V/G/C | Telaprevir, Boceprevir, Vedroprevir, Narlaprevir, Vedroprevir, SCH567312, PHX1766 | Protease | Yes | Sheaffer, 2004.
Sarrazin C, 2007.
Zeuzem S, 2005.
Zeuzem S, 2005.
Tong X, 2006.
Tong X, 2006.
| Sarrazin C, 2007.
Tong X, 2008.
Bartels DJ, 2013.
Kieffer TL, 2012.
Kwong AD, 2011.
Curry S, 2008.
Susser S, 2009.
Gaudieri S, 2009.
Bae A, 2010.
|
|
| 55 | V55A/F/I/K/T | Telaprevir, Boceprevir, Vedroprevir, Danoprevir, Paritaprevir (ABT-450), Sovaprevir, PHX1766 | Protease | Yes | Susser S, 2008.
Qiu P, 2009.
| Bartels DJ, 2013.
Vermehren J, 2012.
Susser S, 2009.
Paolucci S, 2012.
|
|
| 79 | D79E | Telaprevir, Boceprevir | Protease | No | Thibeault D, 2004.
| |
|
| 80 | Q80K/R/L/N/H/G | Telaprevir, Boceprevir, Simeprevir, Asunaprevir, Danoprevir, Vedroprevir, Sovaprevir | Protease | Yes | Lenz O, 2010.
| Bartels DJ, 2013.
Bae A, 2010.
Paolucci S, 2012.
McPhee F, 2012.
|
|
| 87 | A87T | Telaprevir, Boceprevir | Protease | No | Susser S, 2009.
| Besse B, 2012.
Susser S, 2011.
|
|
| 105 | Y105C | Asunaprevir | Protease | No | McPhee F, 2012.
| |
|
| 109 | R109K | Telaprevir, Boceprevir, SCH446211 | Protease | No | Yi M, 2006.
| Bartels DJ, 2008.
|
|
| 117 | R117H | Telaprevir, Boceprevir | Protease | No | Susser S, 2009.
| Besse B, 2012.
Susser S, 2011.
|
|
| 122 | S122G/A/R/N/T | Simeprevir | Protease | No | Tong X, 2006.
McPhee F, 2012.
| McPhee F, 2012.
Tong X, 2014.
|
|
| 123 | R123T | Telaprevir, Ciluprevir | Protease | No | Lin C, 2004.
Tong X, 2006.
| |
|
| 138 | S138T/D/P | Telaprevir, Boceprevir, Danoprevir | Protease | No | Seiwert S. , 2006.
Seiwert SD, 2007.
Imhof I, 2011.
| Besse B, 2012.
|
|
| 155 | R155G/K/T/M/I/L/S/Q/P/N/W | Telaprevir, Boceprevir, Simeprevir, Vedroprevir, Faldaprevir, Danoprevir, Paritaprevir (ABT-450), Asunaprevir, Narlaprevir, GS9256, Grazoprevir (MK5172), BMS-791325, PHX1766 | Protease | Yes | Lin C, 2004.
Sarrazin C, 2007.
Lu L, 2004.
Zhou Y, 2007.
Lagacé Lisette, 2012.
| Sarrazin C, 2007.
Kieffer TL, 2007.
Bartels DJ, 2008.
Bartels DJ, 2013.
Susser S, 2009.
Sarrazin C, 2010.
Colson P, 2008.
|
|
| 156 | A156F/N/S/T/V/I/G/D | Telaprevir, Boceprevir, Simeprevir, Vedroprevir, Faldaprevir, Danoprevir, Paritaprevir (ABT-450), Asunaprevir, Narlaprevir, GS9256, Grazoprevir (MK5172), BMS-791325, SCH567312, PHX1766 | Protease | Yes | Lin C, 2004.
Sheaffer, 2004.
Sarrazin C, 2007.
Tong X, 2006.
Lu L, 2004.
Lin C, 2005.
He Y, 2008.
| Sarrazin C, 2007.
Kieffer TL, 2007.
Hiraga N, 2011.
|
|
| 158 | V158I/M | Boceprevir | Protease | Yes | Kieffer TL, 2007.
Qiu P, 2009.
Flint M, 2009.
| Bartels DJ, 2013.
Kwo PY, 2010.
|
|
| 163 | V163L | Boceprevir | Protease | No | Qiu P, 2009.
Taremi SS, 1998.
| |
|
| 168 | D168Q/A/Y/V/E/T/N/P/I/H/G/F/S/K | Telaprevir, Boceprevir, Simeprevir, Vedroprevir, Faldaprevir, Danoprevir, Paritaprevir (ABT-450), Asunaprevir, Narlaprevir, GS9256, Grazoprevir (MK5172), BMS-791325, Sovaprevir, IDX-320 | Protease | Yes | Lin C, 2004.
Sheaffer, 2004.
Seiwert SD, 2007.
Lu L, 2004.
Lagacé Lisette, 2012.
He Y, 2008.
Koev G, 2007.
| Bartels DJ, 2013.
Vermehren J, 2012.
Bae A, 2010.
Zeuzem S, 2011.
|
|
| 170 | V170A/T/G/L/M | Telaprevir, Boceprevir, Simeprevir, Faldaprevir, Danoprevir, Asunaprevir, Narlaprevir, SCH567312, PHX1766 | Protease | Yes | Zeuzem S, 2005.
Zeuzem S, 2005.
Tong X, 2006.
| Bartels DJ, 2008.
Bartels DJ, 2013.
Curry S, 2008.
Susser S, 2009.
Besse B, 2012.
|
|
| 173 | E173G | Asunaprevir | Protease | No | McPhee F, 2012.
| |
|
| 174 | S174F/P | Telaprevir, Boceprevir, Danoprevir | Protease | No | Imhof I, 2011.
| Besse B, 2012.
Susser S, 2011.
|
|
| 175 | M175L | Telaprevir, Boceprevir | Protease | No | Romano KP, 2010.
| Bartels DJ, 2013.
Paolucci S, 2012.
Barnard RJ, 2013.
|
|
| 176 | E176G | Telaprevir, Boceprevir | Protease | No | Flint M, 2009.
Krieger N, 2001.
Abe K, 2007.
| |
|
| 26 registries |
