Biomedical Mutation Analysis

Positions Amino Acids

Position Mutation Antiviral Inhibitor Main References in vitro References in vivo
15A15GSofosbuvir, PSI-938, PSI-661 NucleosideNoLam AM, 2011.
19T19S/PFilibuvir, VCH-759Non-nucleosideNoHowe AY, 2006.
50K50RBenzothiadiazineNon-nucleosideNoNguyen TT, 2003.
55D55EA782759Non-nucleosideNoMo H, 2005.
71M71VFilibuvir, VCH-759Non-nucleosideNoHowe AY, 2006.
Nguyen TT, 2003.
72K72MMericitabineNucleosideNoAli S, 2008.
95H95Q/RDasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072Non-nucleosideNoMo H, 2005.
Tomei L, 2004.
96S96TSofosbuvir, Balapiravir NucleosideNoLam AM, 2011.
Ali S, 2008.
Le Pogam S, 2006.
138138IA782759Non-nucleosideNoGaudieri S, 2009.
Mo H, 2005.
142N142TBalapiravirNucleosideNoAli S, 2008.
Le Pogam S, 2006.
159L159F PSI-938, PSI-661 NucleosideYesTong X, 2014.
Paolucci S, 2013.
Gane EJ, 2014.
Tong X, 2014.
222R222QSofosbuvir, Mericitabine, PSI-938 NucleosideNoLam AM, 2011.
223C223H/YSofosbuvir, PSI-938, PSI-661 NucleosideNoLam AM, 2011.
239I239V/LMericitabineNucleosideNoAli S, 2008.
282S282T/RSofosbuvir, Mericitabine, IDX184, PSI-938, Valopicitabine NucleosideYesLe Pogam S, 2006.
Migliaccio G, 2003.
Lam AM, 2012.
Tong X, 2014.
Gane EJ, 2014.
300A300TNesbuvirNon-nucleosideNoAli S, 2008.
314L314FNesbuvirNon-nucleosideNoHowe AY, 2008.
316C316Y/F/N/SDasabuvir (ABT-333), BI207127, Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072Non-nucleosideYesFlint M, 2009.
Howe AY, 2008.
Villano Stephen, 2006.
Shi ST, 2008.
Bartels DJ, 2013.
Paolucci S, 2013.
Middleton T, 2010.
Sun SC, 2011.
Zeuzem S, 2012.
Trevino A, 2011.
320L320F/ISofosbuvir, PSI-938, PSI-661 NucleosideYesLam AM, 2011.
Ali S, 2008.
Tong X, 2014.
Gane EJ, 2014.
Tong X, 2014.
321V321ISofosbuvir, PSI-938, PSI-661NucleosideNoLam AM, 2011.
Bartels DJ, 2013.
Paolucci S, 2013.
338A338VA837093Non-nucleosideNoHowe AY, 2006.
363I363VNesbuvirNon-nucleosideNoHowe AY, 2008.
365S365T/A/L/FDasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072Non-nucleosideNoHowe AY, 2008.
McCown MF, 2008.
Hang JQ, 2009.
368S368A/TDasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072Non-nucleosideNoLu L, 2007.
389T389A/SJT-16Non-nucleosideNoDelang L, 2012.
392L392IIndole-N-acetamidesNon-nucleosideNoRydberg EH, 2009.
396A396GMericitabineNucleosideNoAli S, 2008.
411N411SDasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072Non-nucleosideNoNguyen TT, 2003.
Mo H, 2005.
414M414L/T/I/V/QDasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072, GSK-G25433Non-nucleosideYesNguyen TT, 2003.
Mo H, 2005.
Tomei L, 2004.
Howe AY, 2008.
Lu L, 2007.
Thompson PA, 2008.
Koev G, 2009.
Bartels DJ, 2013.
Middleton T, 2010.
419L419M/V/S/IFilibuvir, GS-9669, Lomibuvir, VCH-759, VCH-916, AG-021541, VCH-371Non-nucleosideYesCooper C, 2009.
Le Pogam S, 2006.
Bartels D, 2010.
Zhang EZ, 2012.
421A421VBMS-791325Non-nucleosideNoMcPhee F, 2012.
Bartels DJ, 2013.
422R422KFilibuvir, GS-9669, VCH-759, VCH-916, AG-021541Non-nucleosideNoBartels D, 2010.
Zhang EZ, 2012.
Troke PJ, 2011.
423M423T/V/I/AFilibuvir, GS-9669, VCH-759, VCH-916, AG-021541Non-nucleosideYesHowe AY, 2006.
Shi ST, 2008.
Le Pogam S, 2006.
Bartels DJ, 2013.
Bartels D, 2010.
Troke PJ, 2011.
Mori J, 2010.
424I424VFilibuvir, BILB 1941Non-nucleosideNoAlves R, 2013.
426M426T/V/IFilibuvir, VCH-759, VCH-916, AG-021541Non-nucleosideYesShi ST, 2008.
Paolucci S, 2013.
442A442TFilibuvir, Lomibuvir, VCH-759, VCH-916, VCH-371Non-nucleosideNoHowe AY, 2006.
445C445FTegobuvirNon-nucleosideNoDelang L, 2011.
Bartels DJ, 2013.
Zeuzem S, 2012.
Hebner CW, 2011.
447I447FGSK-G25433Non-nucleosideNoGray F, 2007.
448Y448H/CDasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072, VCH-759, VCH-916Non-nucleosideYesLu L, 2007.
Bartels DJ, 2013.
Middleton T, 2010.
Zeuzem S, 2012.
Lawitz E, 2010.
451C451RDasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072Non-nucleosideNoTomei L, 2004.
452Y452HTegobuvirNon-nucleosideNoShih IH, 2011.
Bartels DJ, 2013.
Paolucci S, 2013.
462I462TFilibuvir, VCH-759, VCH-916, AG-021541Non-nucleosideNoKieffer TL, 2010.
465R465GTegobuvirNon-nucleosideNoShih IH, 2011.
Paolucci S, 2013.
482I482L/V/T/SFilibuvir, GS-9669, Lomibuvir, VCH-759, VCH-916, AG-021541, VCH-371Non-nucleosideYesShi ST, 2008.
Cooper C, 2009.
Le Pogam S, 2006.
Nicolas O, 2008.
Bartels D, 2010.
486A486V/I/T/MGS-9669Non-nucleosideNoBartels D, 2010.
494V494A/IFilibuvir, GS-9669, Lomibuvir, VCH-759, VCH-916, AG-021541, BILB1941Non-nucleosideYesShi ST, 2008.
Cooper C, 2009.
Bartels DJ, 2013.
Bartels D, 2010.
495P495L/A/S/T/QBI207127, BMS-791325, Tegobuvir, MK-3281, JTK-109, BILB1941, JT-16Non-nucleosideNoDelang L, 2012.
Tomei L, 2003.
Lemm JA, 2014.
Zeuzem S, 2011.
496P496A/T/SBI207127, Tegobuvir, MK-3281, JTK-109, BILB1941Non-nucleosideNoKukolj G, 2005.
Bartels DJ, 2013.
499V499ABI207127, Tegobuvir, MK-3281, JTK-109, BILB1941Non-nucleosideNoKukolj G, 2005.
Bartels DJ, 2013.
Gaudieri S, 2009.
Paolucci S, 2013.
Trevino A, 2011.
531R531KNesbuvirNon-nucleosideNoHowe AY, 2006.
Howe AY, 2008.
554G554D/SDasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072Non-nucleosideYesLu L, 2007.
Thompson PA, 2008.
Lu, 2006.
555Y555CTegobuvir, A782759, A837093Non-nucleosideNoLu L, 2007.
556S556G/N/CDasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, Nesbuvir, ABT-072Non-nucleosideYesKoev G, 2009.
Bartels DJ, 2013.
Middleton T, 2010.
Sun SC, 2011.
558G558RDasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072Non-nucleosideNoTomei L, 2004.
559D559G/S/NDasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072Non-nucleosideYesLu L, 2007.
571W571RTegobuvirNon-nucleosideNoShih IH, 2011.
586Y586CMericitabineNucleosideNoAli S, 2008.
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