|
|
Position |
Mutation |
Antiviral |
Inhibitor |
Main |
References in vitro |
References in vivo |
|
| 15 | A15G | Sofosbuvir, PSI-938, PSI-661 | Nucleoside | No | Lam AM, 2011.
| |
|
| 19 | T19S/P | Filibuvir, VCH-759 | Non-nucleoside | No | Howe AY, 2006.
| |
|
| 50 | K50R | Benzothiadiazine | Non-nucleoside | No | Nguyen TT, 2003.
| |
|
| 55 | D55E | A782759 | Non-nucleoside | No | Mo H, 2005.
| |
|
| 71 | M71V | Filibuvir, VCH-759 | Non-nucleoside | No | Howe AY, 2006.
Nguyen TT, 2003.
| |
|
| 72 | K72M | Mericitabine | Nucleoside | No | Ali S, 2008.
| |
|
| 95 | H95Q/R | Dasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072 | Non-nucleoside | No | Mo H, 2005.
Tomei L, 2004.
| |
|
| 96 | S96T | Sofosbuvir, Balapiravir | Nucleoside | No | Lam AM, 2011.
Ali S, 2008.
Le Pogam S, 2006.
| |
|
| 138 | 138I | A782759 | Non-nucleoside | No | Gaudieri S, 2009.
Mo H, 2005.
| |
|
| 142 | N142T | Balapiravir | Nucleoside | No | Ali S, 2008.
Le Pogam S, 2006.
| |
|
| 159 | L159F | PSI-938, PSI-661 | Nucleoside | Yes | Tong X, 2014.
| Paolucci S, 2013.
Gane EJ, 2014.
Tong X, 2014.
|
|
| 222 | R222Q | Sofosbuvir, Mericitabine, PSI-938 | Nucleoside | No | Lam AM, 2011.
| |
|
| 223 | C223H/Y | Sofosbuvir, PSI-938, PSI-661 | Nucleoside | No | Lam AM, 2011.
| |
|
| 239 | I239V/L | Mericitabine | Nucleoside | No | Ali S, 2008.
| |
|
| 282 | S282T/R | Sofosbuvir, Mericitabine, IDX184, PSI-938, Valopicitabine | Nucleoside | Yes | Le Pogam S, 2006.
Migliaccio G, 2003.
Lam AM, 2012.
| Tong X, 2014.
Gane EJ, 2014.
|
|
| 300 | A300T | Nesbuvir | Non-nucleoside | No | Ali S, 2008.
| |
|
| 314 | L314F | Nesbuvir | Non-nucleoside | No | Howe AY, 2008.
| |
|
| 316 | C316Y/F/N/S | Dasabuvir (ABT-333), BI207127, Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072 | Non-nucleoside | Yes | Flint M, 2009.
Howe AY, 2008.
Villano Stephen, 2006.
Shi ST, 2008.
| Bartels DJ, 2013.
Paolucci S, 2013.
Middleton T, 2010.
Sun SC, 2011.
Zeuzem S, 2012.
Trevino A, 2011.
|
|
| 320 | L320F/I | Sofosbuvir, PSI-938, PSI-661 | Nucleoside | Yes | Lam AM, 2011.
Ali S, 2008.
Tong X, 2014.
| Gane EJ, 2014.
Tong X, 2014.
|
|
| 321 | V321I | Sofosbuvir, PSI-938, PSI-661 | Nucleoside | No | Lam AM, 2011.
| Bartels DJ, 2013.
Paolucci S, 2013.
|
|
| 338 | A338V | A837093 | Non-nucleoside | No | Howe AY, 2006.
| |
|
| 363 | I363V | Nesbuvir | Non-nucleoside | No | Howe AY, 2008.
| |
|
| 365 | S365T/A/L/F | Dasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072 | Non-nucleoside | No | Howe AY, 2008.
McCown MF, 2008.
Hang JQ, 2009.
| |
|
| 368 | S368A/T | Dasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072 | Non-nucleoside | No | Lu L, 2007.
| |
|
| 389 | T389A/S | JT-16 | Non-nucleoside | No | Delang L, 2012.
| |
|
| 392 | L392I | Indole-N-acetamides | Non-nucleoside | No | Rydberg EH, 2009.
| |
|
| 396 | A396G | Mericitabine | Nucleoside | No | Ali S, 2008.
| |
|
| 411 | N411S | Dasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072 | Non-nucleoside | No | Nguyen TT, 2003.
Mo H, 2005.
| |
|
| 414 | M414L/T/I/V/Q | Dasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072, GSK-G25433 | Non-nucleoside | Yes | Nguyen TT, 2003.
Mo H, 2005.
Tomei L, 2004.
Howe AY, 2008.
Lu L, 2007.
Thompson PA, 2008.
Koev G, 2009.
| Bartels DJ, 2013.
Middleton T, 2010.
|
|
| 419 | L419M/V/S/I | Filibuvir, GS-9669, Lomibuvir, VCH-759, VCH-916, AG-021541, VCH-371 | Non-nucleoside | Yes | Cooper C, 2009.
Le Pogam S, 2006.
| Bartels D, 2010.
Zhang EZ, 2012.
|
|
| 421 | A421V | BMS-791325 | Non-nucleoside | No | McPhee F, 2012.
| Bartels DJ, 2013.
|
|
| 422 | R422K | Filibuvir, GS-9669, VCH-759, VCH-916, AG-021541 | Non-nucleoside | No | | Bartels D, 2010.
Zhang EZ, 2012.
Troke PJ, 2011.
|
|
| 423 | M423T/V/I/A | Filibuvir, GS-9669, VCH-759, VCH-916, AG-021541 | Non-nucleoside | Yes | Howe AY, 2006.
Shi ST, 2008.
Le Pogam S, 2006.
| Bartels DJ, 2013.
Bartels D, 2010.
Troke PJ, 2011.
Mori J, 2010.
|
|
| 424 | I424V | Filibuvir, BILB 1941 | Non-nucleoside | No | Alves R, 2013.
| |
|
| 426 | M426T/V/I | Filibuvir, VCH-759, VCH-916, AG-021541 | Non-nucleoside | Yes | Shi ST, 2008.
| Paolucci S, 2013.
|
|
| 442 | A442T | Filibuvir, Lomibuvir, VCH-759, VCH-916, VCH-371 | Non-nucleoside | No | Howe AY, 2006.
| |
|
| 445 | C445F | Tegobuvir | Non-nucleoside | No | Delang L, 2011.
| Bartels DJ, 2013.
Zeuzem S, 2012.
Hebner CW, 2011.
|
|
| 447 | I447F | GSK-G25433 | Non-nucleoside | No | Gray F, 2007.
| |
|
| 448 | Y448H/C | Dasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072, VCH-759, VCH-916 | Non-nucleoside | Yes | Lu L, 2007.
| Bartels DJ, 2013.
Middleton T, 2010.
Zeuzem S, 2012.
Lawitz E, 2010.
|
|
| 451 | C451R | Dasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072 | Non-nucleoside | No | Tomei L, 2004.
| |
|
| 452 | Y452H | Tegobuvir | Non-nucleoside | No | Shih IH, 2011.
| Bartels DJ, 2013.
Paolucci S, 2013.
|
|
| 462 | I462T | Filibuvir, VCH-759, VCH-916, AG-021541 | Non-nucleoside | No | Kieffer TL, 2010.
| |
|
| 465 | R465G | Tegobuvir | Non-nucleoside | No | Shih IH, 2011.
| Paolucci S, 2013.
|
|
| 482 | I482L/V/T/S | Filibuvir, GS-9669, Lomibuvir, VCH-759, VCH-916, AG-021541, VCH-371 | Non-nucleoside | Yes | Shi ST, 2008.
Cooper C, 2009.
Le Pogam S, 2006.
Nicolas O, 2008.
| Bartels D, 2010.
|
|
| 486 | A486V/I/T/M | GS-9669 | Non-nucleoside | No | | Bartels D, 2010.
|
|
| 494 | V494A/I | Filibuvir, GS-9669, Lomibuvir, VCH-759, VCH-916, AG-021541, BILB1941 | Non-nucleoside | Yes | Shi ST, 2008.
Cooper C, 2009.
| Bartels DJ, 2013.
Bartels D, 2010.
|
|
| 495 | P495L/A/S/T/Q | BI207127, BMS-791325, Tegobuvir, MK-3281, JTK-109, BILB1941, JT-16 | Non-nucleoside | No | Delang L, 2012.
Tomei L, 2003.
Lemm JA, 2014.
| Zeuzem S, 2011.
|
|
| 496 | P496A/T/S | BI207127, Tegobuvir, MK-3281, JTK-109, BILB1941 | Non-nucleoside | No | Kukolj G, 2005.
| Bartels DJ, 2013.
|
|
| 499 | V499A | BI207127, Tegobuvir, MK-3281, JTK-109, BILB1941 | Non-nucleoside | No | Kukolj G, 2005.
| Bartels DJ, 2013.
Gaudieri S, 2009.
Paolucci S, 2013.
Trevino A, 2011.
|
|
| 531 | R531K | Nesbuvir | Non-nucleoside | No | Howe AY, 2006.
| Howe AY, 2008.
|
|
| 554 | G554D/S | Dasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072 | Non-nucleoside | Yes | Lu L, 2007.
Thompson PA, 2008.
Lu, 2006.
| |
|
| 555 | Y555C | Tegobuvir, A782759, A837093 | Non-nucleoside | No | Lu L, 2007.
| |
|
| 556 | S556G/N/C | Dasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, Nesbuvir, ABT-072 | Non-nucleoside | Yes | Koev G, 2009.
| Bartels DJ, 2013.
Middleton T, 2010.
Sun SC, 2011.
|
|
| 558 | G558R | Dasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072 | Non-nucleoside | No | Tomei L, 2004.
| |
|
| 559 | D559G/S/N | Dasabuvir (ABT-333), Setrobuvir, Tegobuvir, A782759, A837093, Nesbuvir, ABT-072 | Non-nucleoside | Yes | Lu L, 2007.
| |
|
| 571 | W571R | Tegobuvir | Non-nucleoside | No | Shih IH, 2011.
| |
|
| 586 | Y586C | Mericitabine | Nucleoside | No | Ali S, 2008.
| |
|
| 57 registries |
