|
|
Position |
Mutation |
Antiviral |
Inhibitor |
Main |
References in vitro |
References in vivo |
|
| 23 | L23F | Daclastavir (BMS-790052) | | Yes | Fridell RA, 2010.
| |
|
| 28 | L28M | Daclastavir (BMS-790052), Ledispasvir (GS-5885), Ombitasvir(ABT-267), Samatasvir (IDX-719) | | No | Pawlotsky JM. , 2013.
| Karino Y, 2013.
|
|
| 30 | R30Q/L | Daclastavir (BMS-790052), Ledispasvir (GS-5885), Ombitasvir (ABT-267) | | Yes | Fridell RA, 2010.
Sun JH, 2012.
| Peres-da-Silva A, 2014.
|
|
| 31 | L31M/V/F | Daclastavir (BMS-790052), Ledispasvir (GS-5885), Samatasvir (IDX-719), Ombitasvir (ABT-267), Elbasvir (MK-8742) | | Yes | Lemm JA, 2010.
Fridell RA, 2010.
Fridell RA, 2011.
Gao M, 2010.
Wang C, 2012.
| Spreen W, 2011.
Karino Y, 2013.
Peres-da-Silva A, 2014.
|
|
| 32 | P32L | Daclastavir (BMS-790052), GSK-805 | | Yes | Fridell RA, 2010.
Spreen W, 2011.
| |
|
| 54 | Q54H/N | Daclastavir (BMS-790052) | | Yes | Fridell RA, 2011.
Pawlotsky JM. , 2013.
| |
|
| 58 | P58S/A/L/T/H | Ledispasvir (GS-5885), Ombitasvir (ABT-267) | | Yes | Fridell RA, 2010.
Hui-Mei Lin, 2012.
Wang C, 2012.
Lin HM, 2013.
| Peres-da-Silva A, 2014.
|
|
| 93 | Y93H/N/C | Daclastavir (BMS-790052), Ledispasvir (GS-5885), Ombitasvir (ABT-267), Samatasvir (IDX-719), Elbasvir (MK-8742) | | Yes | Lemm JA, 2010.
Fridell RA, 2010.
Fridell RA, 2011.
Hui-Mei Lin, 2012.
Gao M, 2010.
Wang C, 2012.
Lin HM, 2013.
| Karino Y, 2013.
Peres-da-Silva A, 2014.
|
|
| 8 registries |
