Biomedical Mutation Analysis

Positions Amino Acids

Position Mutation Antiviral Inhibitor Main References in vitro References in vivo
23L23FDaclastavir (BMS-790052)YesFridell RA, 2010.
28L28MDaclastavir (BMS-790052), Ledispasvir (GS-5885), Ombitasvir(ABT-267), Samatasvir (IDX-719)NoPawlotsky JM. , 2013.
Karino Y, 2013.
30R30Q/LDaclastavir (BMS-790052), Ledispasvir (GS-5885), Ombitasvir (ABT-267)YesFridell RA, 2010.
Sun JH, 2012.
Peres-da-Silva A, 2014.
31L31M/V/FDaclastavir (BMS-790052), Ledispasvir (GS-5885), Samatasvir (IDX-719), Ombitasvir (ABT-267), Elbasvir (MK-8742)YesLemm JA, 2010.
Fridell RA, 2010.
Fridell RA, 2011.
Gao M, 2010.
Wang C, 2012.
Spreen W, 2011.
Karino Y, 2013.
Peres-da-Silva A, 2014.
32P32LDaclastavir (BMS-790052), GSK-805YesFridell RA, 2010.
Spreen W, 2011.
54Q54H/NDaclastavir (BMS-790052)YesFridell RA, 2011.
Pawlotsky JM. , 2013.
58P58S/A/L/T/HLedispasvir (GS-5885), Ombitasvir (ABT-267)YesFridell RA, 2010.
Hui-Mei Lin, 2012.
Wang C, 2012.
Lin HM, 2013.
Peres-da-Silva A, 2014.
93Y93H/N/CDaclastavir (BMS-790052), Ledispasvir (GS-5885), Ombitasvir (ABT-267), Samatasvir (IDX-719), Elbasvir (MK-8742)YesLemm JA, 2010.
Fridell RA, 2010.
Fridell RA, 2011.
Hui-Mei Lin, 2012.
Gao M, 2010.
Wang C, 2012.
Lin HM, 2013.
Karino Y, 2013.
Peres-da-Silva A, 2014.
8 registries
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